{"product_id":"igf-1-lr3-1mg","title":"IGF-1 LR3 1mg","description":"\u003cdiv class=\"markdown markdown-main-panel md-content enable-updated-hr-color force-compact-layout stronger tutor-markdown-rendering\" id=\"model-response-message-contentr_10566e70cbe16624\" dir=\"ltr\"\u003e\n\u003cdiv\u003e\n\u003cb\u003eSafe Vials\u003c\/b\u003e IGF-1 LR3 (Long R3 IGF-1) is a high-purity, laboratory-grade recombinant analog of human insulin-like growth factor 1. Engineered as an 83-amino acid protein, it incorporates two major modifications relative to native IGF-1: a glutamic acid-to-arginine substitution at position 3 (\u003cem\u003e\u003cstrong\u003eArg³\u003c\/strong\u003e\u003c\/em\u003e) and a 13-amino acid extension on its N-terminus.\u003c\/div\u003e\n\u003cbr\u003e\n\u003cdiv\u003eBoth structural alterations work synergistically to drastically reduce the protein’s binding affinity for IGF-binding proteins (\u003cem\u003e\u003cstrong\u003eIGFBPs\u003c\/strong\u003e\u003c\/em\u003e). In native biological systems, \u003cem\u003eIGFBPs\u003c\/em\u003e sequester circulating IGF-1, rendering it inactive. By resisting \u003cem\u003eIGFBP\u003c\/em\u003e complexation, \u003cb\u003eSafe Vials\u003c\/b\u003e IGF-1 LR3 remains freely available to engage the IGF-1 receptor (\u003cem\u003e\u003cstrong\u003eIGF-1R\u003c\/strong\u003e\u003c\/em\u003e), driving the downstream \u003cem\u003ePI3K\/Akt\u003c\/em\u003e signaling cascade that regulates cellular proliferation, survival, and protein synthesis. Every lot is independently third-party tested and HPLC-verified (\u003cem\u003e\u003cstrong\u003e≥ 95%\u003c\/strong\u003e\u003c\/em\u003e purity) to ensure maximum activity and inter-assay consistency.\u003c\/div\u003e\n\u003cbr\u003e\u003chr\u003e\n\u003ch2\u003eCompound Information\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eProduct Name:\u003c\/b\u003e Safe Vials IGF-1 LR3\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eClassification:\u003c\/b\u003e Recombinant Growth Factor Analog (\u003cem\u003e\u003cstrong\u003eIGF-1R\u003c\/strong\u003e\u003c\/em\u003e Agonist)\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eCAS Registry Number:\u003c\/b\u003e \u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e946870-92-4\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\u003cb\u003eMolecular Formula: \u003cspan\u003eC₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉\u003c\/span\u003e\u003c\/b\u003e\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eMolecular Weight:\u003c\/b\u003e 9111.00 g\/mol (approx.)\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eStructure \u0026amp; Length:\u003c\/b\u003e 83 Amino Acids (70 AA IGF-1 core + 13 AA N-terminal extension, \u003cem\u003eArg³\u003c\/em\u003e substitution, 3 internal disulfide bridges)\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eSynonyms:\u003c\/b\u003e Long R3 IGF-1, LR3 IGF-1, Recombinant Human IGF-1 LR3\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eResearch Highlights\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eResistance to IGFBP Sequestration:\u003c\/b\u003e The \u003cem\u003eArg³\u003c\/em\u003e mutation and N-terminal extension sharply lower affinity for binding proteins, maintaining high free concentration for receptor interaction.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eCell Culture Media Standard:\u003c\/b\u003e Widely utilized as a core supplement in serum-free and reduced-serum media, offering higher functional availability than native IGF-1.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003ePI3K\/Akt Pathway Engagement:\u003c\/b\u003e Binds \u003cem\u003eIGF-1R\u003c\/em\u003e to activate the central \u003cem\u003ePI3K\/Akt\u003c\/em\u003e signaling cascade, a foundational axis in cell survival and protein synthesis research.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eMyoblast \u0026amp; Fibroblast Proliferation:\u003c\/b\u003e Frequently applied in muscle cell and tissue engineering protocols to track cell division and proliferation rates.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eFolded Protein Dynamics:\u003c\/b\u003e Features three essential intra-molecular disulfide bridges that maintain the tertiary structure necessary for receptor activation.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eAnalytical Quality Control:\u003c\/b\u003e Independently verified via third-party HPLC (\u003cem\u003e\u003cstrong\u003e≥ 95%\u003c\/strong\u003e\u003c\/em\u003e purity) to guarantee reliable, batch-to-batch operational activity.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003ePhysical Form:\u003c\/b\u003e Solid lyophilized powder\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eVisual Appearance:\u003c\/b\u003e Fine white to off-white cake\/powder\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003ePurity Level:\u003c\/b\u003e \u003cem\u003e\u003cstrong\u003e≥ 95%\u003c\/strong\u003e\u003c\/em\u003e (HPLC Verified)\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eSolubility:\u003c\/b\u003e Soluble in dilute acetic acid or bacteriostatic water\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\u003cb\u003eStorage Requirements:\u003c\/b\u003e\u003c\/div\u003e\n\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003ci\u003eUnopened (Lyophilized):\u003c\/i\u003e Keep sealed and dry at \u003cb\u003e-20°C\u003c\/b\u003e for long-term preservation (or \u003cb\u003e2–8°C\u003c\/b\u003e for short-term handling). Protect from direct light.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003ci\u003eReconstituted Solution:\u003c\/i\u003e Store under refrigeration at \u003cb\u003e2°C – 8°C\u003c\/b\u003e. Aliquot into single-use working volumes; avoid repeated freeze-thaw cycles, high heat, physical agitation, or strong reducing agents that break disulfide bridges.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eUsage Disclaimer:\u003c\/b\u003e Strictly for \u003ci\u003eIn Vitro\u003c\/i\u003e Laboratory Research and Development Use Only. Must be handled by qualified professionals. Not for human, therapeutic, or diagnostic applications.\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"Safe Vials","offers":[{"title":"Default Title","offer_id":57892169384318,"sku":null,"price":118.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/9109\/9518\/files\/IGF-1LR3_1mg.png?v=1787290005","url":"https:\/\/safevials.com\/products\/igf-1-lr3-1mg","provider":"Safe Vials","version":"1.0","type":"link"}