{"product_id":"ll-37-5mg","title":"LL-37 5mg","description":"\u003cdiv class=\"markdown markdown-main-panel md-content enable-updated-hr-color force-compact-layout stronger tutor-markdown-rendering\" id=\"model-response-message-contentr_b9a42b6d73725b5c\" dir=\"ltr\"\u003e\n\u003cdiv\u003e\n\u003cb\u003eSafe Vials\u003c\/b\u003e LL-37 is a high-purity, laboratory-grade synthetic 37-amino acid cationic peptide corresponding to the C-terminal fragment of human cathelicidin (hCAP18). As the sole cathelicidin-derived antimicrobial peptide identified in humans, LL-37 plays a foundational role in host defense mechanisms across mucosal and epithelial surfaces.\u003c\/div\u003e\n\u003cbr\u003e\n\u003cdiv\u003eCharacterized by its amphipathic \u003cem\u003eα\u003c\/em\u003e-helical conformation and high net positive charge, \u003cb\u003eSafe Vials\u003c\/b\u003e LL-37 is widely utilized in lipid bilayer disruption models to examine non-specific membrane interaction dynamics. Beyond direct antimicrobial activity, it serves as an indispensable signaling reference probe in immunomodulatory research—specifically for evaluating cell recruitment via chemotaxis, pro- and anti-inflammatory cytokine expression, and cell migration in re-epithelialization and wound-healing assays. Every lot is independently third-party tested and HPLC-verified (\u003cem\u003e\u003cstrong\u003e≥ 98%\u003c\/strong\u003e\u003c\/em\u003e purity) to guarantee high batch-to-batch consistency and reproducible quantitative results.\u003c\/div\u003e\n\u003cbr\u003e\u003chr\u003e\n\u003ch2\u003eCompound Information\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eProduct Name:\u003c\/b\u003e Safe Vials LL-37\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eClassification:\u003c\/b\u003e Cationic Antimicrobial Peptide (Cathelicidin \/ AMP)\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eCAS Registry Number:\u003c\/b\u003e \u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e154947-66-7\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\n\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eMolecular Formula:\u003c\/b\u003e \u003cem\u003e\u003cstrong\u003eC₂₀₅H₃₄₀N₆₀O₅₃\u003c\/strong\u003e\u003c\/em\u003e\n\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eMolecular Weight:\u003c\/b\u003e 4493.33 g\/mol\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eSequence:\u003c\/b\u003e Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser (37 Amino Acids)\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eSynonyms:\u003c\/b\u003e Cathelicidin, hCAP18 (104–140), CAMP\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eResearch Highlights\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eHuman Cathelicidin Benchmark:\u003c\/b\u003e Serves as the primary human cathelicidin reference compound for studying innate host-defense mechanisms at skin and mucosal interfaces.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eAmphipathic Membrane Interactions:\u003c\/b\u003e The cationic \u003cspan class=\"math-inline\"\u003e$\\alpha$\u003c\/span\u003e-helical structure makes it an essential model for examining electrostatic attraction to anionic lipid bilayers and membrane disruption kinetics.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eImmunomodulatory \u0026amp; Chemotactic Signaling:\u003c\/b\u003e Widely applied in cell culture protocols to monitor immune cell recruitment, receptor interaction (e.g., FPR2), and downstream cytokine cascades.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eEpithelial Repair \u0026amp; Angiogenesis:\u003c\/b\u003e Evaluated in wound-healing models to observe keratinocyte migration, re-epithelialization rates, and endothelial tube formation.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eBroad Antimicrobial Standard:\u003c\/b\u003e Functions as a control benchmark in comparative assays evaluating novel synthetic antimicrobial peptide candidates.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eAnalytical Purity Verification:\u003c\/b\u003e Independently verified via third-party HPLC testing (\u003cem\u003e\u003cstrong\u003e≥ 98%\u003c\/strong\u003e\u003c\/em\u003e purity) to ensure clean, consistent performance in analytical protocols.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003ePhysical Form:\u003c\/b\u003e Solid lyophilized powder\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eVisual Appearance:\u003c\/b\u003e Fine white to off-white cake\/powder\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003ePurity Level:\u003c\/b\u003e \u003cem\u003e\u003cstrong\u003e≥ 98%\u003c\/strong\u003e\u003c\/em\u003e (HPLC Verified)\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eSolubility:\u003c\/b\u003e Readily soluble in sterile water or bacteriostatic water \u003ci\u003e(Note: Highly cationic peptide—use low-binding plasticware where possible to minimize surface adsorption)\u003c\/i\u003e\n\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\u003cb\u003eStorage Requirements:\u003c\/b\u003e\u003c\/div\u003e\n\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003ci\u003eUnopened (Lyophilized):\u003c\/i\u003e Keep tightly sealed and dry at \u003cb\u003e-20°C\u003c\/b\u003e for long-term storage (or \u003cb\u003e2–8°C\u003c\/b\u003e for short-term handling). Protect from light and moisture.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003ci\u003eReconstituted Solution:\u003c\/i\u003e Store under refrigeration at \u003cb\u003e2°C – 8°C\u003c\/b\u003e. Aliquot working stock solutions to prevent structural degradation from repeated freeze-thaw cycles.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eUsage Disclaimer:\u003c\/b\u003e Strictly for \u003ci\u003eIn Vitro\u003c\/i\u003e Laboratory Research and Development Use Only. Must be handled by qualified professionals. Not for human, therapeutic, or diagnostic applications.\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"Safe Vials","offers":[{"title":"Default Title","offer_id":57898800087422,"sku":null,"price":73.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/9109\/9518\/files\/LL-37_5mg.png?v=1787371846","url":"https:\/\/safevials.com\/products\/ll-37-5mg","provider":"Safe Vials","version":"1.0","type":"link"}