{"product_id":"mots-c","title":"MOTS-C","description":"\u003cp\u003e\u003cb\u003eSafe Vials\u003c\/b\u003e MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a high-purity, laboratory-grade 16-residue peptide derived directly from the mitochondrial genome rather than nuclear DNA. Belonging to an emerging class of mitochondrial-derived peptides (MDPs), MOTS-c serves as a critical retrograde signaling molecule that translocates from the mitochondrion to the nucleus to regulate stress-responsive nuclear gene expression.\u003c\/p\u003e\n\u003cp\u003eSpecifically engineered for high reproducibility across research protocols, \u003cb\u003eSafe Vials\u003c\/b\u003e MOTS-c is widely utilized in studies evaluating AMP-activated protein kinase (AMPK) activation, cellular energy regulation, skeletal muscle glucose handling, and folate–methionine pathway dynamics. Every lot is HPLC-verified to ensure maximum purity, providing researchers with a dependable, contaminant-free standard for advanced \u003ci\u003ein vitro\u003c\/i\u003e and cellular assays.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eCompound Information\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eProduct Name:\u003c\/b\u003e Safe Vials MOTS-c\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eClassification:\u003c\/b\u003e Mitochondrial-Derived Peptide (MDP) \/ Metabolic Regulator\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eCAS Registry Number:\u003c\/b\u003e 1627580-64-6\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eMolecular Formula:\u003c\/b\u003e \u003cem\u003e\u003cstrong\u003eC₁₀₁H₁₅₁N₂₉O₂₂S₂\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eMolecular Weight:\u003c\/b\u003e 2174.62 g\/mol\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eSequence:\u003c\/b\u003e Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (16 Amino Acids)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eGene Origin:\u003c\/b\u003e Encoded within the mtDNA 12S rRNA region\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eResearch Highlights\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eRetrograde Nuclear Signaling:\u003c\/b\u003e Acts as an essential reference model for retrograde signaling, demonstrating how mitochondrial activity directly influences nuclear transcription during cellular stress.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eAMPK Pathway Engagement:\u003c\/b\u003e Actively researched alongside compounds like AICAR for its role in stimulating AMP-activated protein kinase (AMPK) and promoting metabolic equilibrium.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eGlucose Homeostasis \u0026amp; Insulin Sensitivity:\u003c\/b\u003e Extensively cited in skeletal muscle and systemic metabolic models examining cellular glucose uptake and metabolic flexibility.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eFolate–Methionine Cycle Interaction:\u003c\/b\u003e Modulates one-carbon metabolism, offering insights into the regulatory link between mitochondrial signaling and nuclear methylation processes.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eHigh-Purity Stability:\u003c\/b\u003e Supplied in a verified, highly stable lyophilized format to maintain peptide structural integrity over prolonged laboratory studies.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003ePhysical Form:\u003c\/b\u003e Solid lyophilized powder\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eVisual Appearance:\u003c\/b\u003e Fine white to off-white powder\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003ePurity Level:\u003c\/b\u003e \u003cstrong\u003e≥ 98%\u003c\/strong\u003e (HPLC verified)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eSolubility:\u003c\/b\u003e Soluble in sterile water or bacteriostatic water\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eStorage \u0026amp; Stability Requirements:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003ci\u003eUnopened (Lyophilized):\u003c\/i\u003e Keep sealed and dry at \u003cb\u003e-20°C\u003c\/b\u003e for long-term storage (or \u003cb\u003e2–8°C\u003c\/b\u003e for short-term handling). Protect from light and moisture. \u003ci\u003eNote:\u003c\/i\u003e Contains methionine residues—minimize direct exposure to air and strong oxidizing agents.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003ci\u003eReconstituted Solution:\u003c\/i\u003e Aliquot and store under refrigeration at \u003cb\u003e2°C – 8°C\u003c\/b\u003e. Avoid repeated freeze-thaw cycles to preserve peptide structure.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cb\u003eUsage Disclaimer:\u003c\/b\u003e Strictly for \u003ci\u003eIn Vitro\u003c\/i\u003e Laboratory Research and Development Use Only. Not for human consumption, therapeutic, or diagnostic applications.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Safe Vials","offers":[{"title":"10mg","offer_id":57863777616254,"sku":null,"price":76.0,"currency_code":"CAD","in_stock":true},{"title":"40mg","offer_id":57863777649022,"sku":null,"price":188.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/9109\/9518\/files\/MOTS-C_10mg.png?v=1787137471","url":"https:\/\/safevials.com\/products\/mots-c","provider":"Safe Vials","version":"1.0","type":"link"}