{"product_id":"tb500-10mg","title":"TB500 10mg","description":"\u003cdiv class=\"markdown markdown-main-panel md-content enable-updated-hr-color force-compact-layout stronger tutor-markdown-rendering\" id=\"model-response-message-contentr_72e35b744f3720fc\" dir=\"ltr\"\u003e\n\u003cdiv\u003e\n\u003cb\u003eSafe Vials\u003c\/b\u003e TB-500 is a high-purity, laboratory-grade synthetic 7-amino acid peptide corresponding specifically to the active actin-binding domain (\u003cem\u003e\u003cstrong\u003eAc-LKKTETQ\u003c\/strong\u003e\u003c\/em\u003e) of Thymosin Beta-4 (\u003cem\u003e\u003cstrong\u003eTβ₄\u003c\/strong\u003e\u003c\/em\u003e). While naturally occurring \u003cem\u003e\u003cstrong\u003eTβ₄\u003c\/strong\u003e\u003c\/em\u003e is a full-length 43-residue protein, isolating this essential heptapeptide fragment provides researchers with a highly stable, compact, and easily dissolvable tool to study cytoskeletal dynamics without the handling complexity of the parent protein.\u003c\/div\u003e\n\u003cbr\u003e\n\u003cdiv\u003eEngineered with an N-terminal acetyl cap for enhanced metabolic stability against enzymatic cleavage, \u003cb\u003eSafe Vials\u003c\/b\u003e TB-500 regulates the monomeric G-actin pool available for microfilament polymerization. This mechanism makes it a fundamental reference compound for \u003ci\u003ein vitro\u003c\/i\u003e scratch assays, directional cell motility studies, and vascular endothelial network formation. Every lot is independently third-party tested and HPLC-verified (\u003cem\u003e\u003cstrong\u003e≥ 99%\u003c\/strong\u003e\u003c\/em\u003e purity) to ensure precise concentration and maximum experimental reproducibility.\u003c\/div\u003e\n\u003cbr\u003e\u003chr\u003e\n\u003ch2\u003eCompound Information\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eProduct Name:\u003c\/b\u003e Safe Vials TB-500\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eClassification:\u003c\/b\u003e Thymosin \u003cem\u003e\u003cstrong\u003eTβ₄\u003c\/strong\u003e\u003c\/em\u003e Fragment \/ Actin-Binding Domain\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eCAS Registry Number:\u003c\/b\u003e 885340-08-9\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eMolecular Formula:\u003c\/b\u003e \u003cstrong\u003e\u003cem\u003eC₃₇H₆₅N₁₁O₁₃\u003c\/em\u003e\u003c\/strong\u003e\n\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eMolecular Weight:\u003c\/b\u003e 888.00 g\/mol\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eSequence:\u003c\/b\u003e Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (7 Amino Acids, N-terminally acetylated)\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eSynonyms:\u003c\/b\u003e \u003cem\u003e\u003cstrong\u003eTβ₄\u003c\/strong\u003e\u003c\/em\u003e Fragment (17–23), Thymosin Beta-4 Active Domain, Ac-LKKTETQ\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eResearch Highlights\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eTargeted Actin Sequestration:\u003c\/b\u003e Faithfully reproduces the core LKKTETQ motif responsible for binding monomeric G-actin, directly influencing filament assembly and cellular architectural remodeling.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eCell Migration \u0026amp; Motility:\u003c\/b\u003e Widely utilized in transwell migration and scratch assays to measure cytoskeletal reorganization velocity and cellular motility patterns \u003ci\u003ein vitro\u003c\/i\u003e.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eVascular \u0026amp; Angiogenic Signaling:\u003c\/b\u003e Frequently investigated in endothelial cell models to examine capillary tube formation and tissue remodeling pathways.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eAcetylated N-Terminus Stability:\u003c\/b\u003e Features an acetyl cap at the N-terminus that significantly improves peptide stability against aminopeptidase degradation compared to free-amine variants.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eCompact \u0026amp; Efficient Handling:\u003c\/b\u003e The 7-residue sequence is significantly simpler to handle, reconstitute, and dose than full-length 43-residue \u003cem\u003e\u003cstrong\u003eTβ₄\u003c\/strong\u003e\u003c\/em\u003e while isolating its core active region.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eAnalytical Purity Verification:\u003c\/b\u003e Independently tested and HPLC-verified (\u003cem\u003e\u003cstrong\u003e≥ 99%\u003c\/strong\u003e\u003c\/em\u003e purity) to ensure reliable, batch-to-batch consistency across extended research protocols.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003ePhysical Form:\u003c\/b\u003e Solid lyophilized powder\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eVisual Appearance:\u003c\/b\u003e Fine white to off-white cake\/powder\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003ePurity Level:\u003c\/b\u003e \u003cem\u003e\u003cstrong\u003e≥ 99%\u003c\/strong\u003e\u003c\/em\u003e (HPLC Verified)\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eSolubility:\u003c\/b\u003e Readily soluble in sterile water or bacteriostatic water\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\u003cb\u003eStorage Requirements:\u003c\/b\u003e\u003c\/div\u003e\n\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003ci\u003eUnopened (Lyophilized):\u003c\/i\u003e Keep sealed and dry at \u003cb\u003e-20°C\u003c\/b\u003e for long-term preservation (or \u003cb\u003e2–8°C\u003c\/b\u003e for short-term handling). Protect from direct light and atmospheric moisture.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003ci\u003eReconstituted Solution:\u003c\/i\u003e Store under refrigeration at \u003cb\u003e2°C – 8°C\u003c\/b\u003e. Aliquot working stocks to prevent degradation from repeated freeze-thaw cycles.\u003c\/div\u003e\n\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cb\u003eUsage Disclaimer:\u003c\/b\u003e Strictly for \u003ci\u003eIn Vitro\u003c\/i\u003e Laboratory Research and Development Use Only. Not for human consumption, therapeutic, or diagnostic applications.\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"Safe Vials","offers":[{"title":"Default Title","offer_id":57867884364158,"sku":null,"price":91.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/9109\/9518\/files\/TB500_10mg.png?v=1787137471","url":"https:\/\/safevials.com\/products\/tb500-10mg","provider":"Safe Vials","version":"1.0","type":"link"}