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Safe Vials

AICAR 50mg

AICAR 50mg

+99% Purity Third-Party Tested COA Available
$73.00
$73.00
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Strictly for laboratory research and development use only. Not for human, therapeutic, or diagnostic applications.

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Description

Safe Vials AICAR (Acadesine / AICA Riboside) is a high-purity, laboratory-grade synthetic nucleoside analog designed to study master metabolic regulation pathways. Functioning as an cell-permeable precursor, AICAR enters target cells where adenosine kinase phosphorylates it into its active monophosphorylated form, ZMP (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl-5'-monophosphate).

Because ZMP structurally mimics adenosine monophosphate (AMP), it binds directly to the γ-subunit of AMP-activated protein kinase (AMPK) to induce allosteric activation and promote phosphorylation. Crucially, Safe Vials AICAR activates the central AMPK cascade without depleting intracellular ATP stores or altering adenylate energy charge ratios. This makes it a gold-standard reference compound for isolating AMPK-dependent downstream metabolic events, including GLUT4 glucose transporter translocation, fatty acid oxidation, and PGC-1α-mediated mitochondrial biogenesis. Every batch is independently third-party tested and HPLC-verified ((≥ 99% purity) to guarantee high experimental stability and batch-to-batch reproducibility.

Compound Information

  • Product Name: Safe Vials AICAR

  • Classification: AMPK Activator / Nucleoside Analog (Exercise Mimetic Probe)

  • CAS Registry Number: 2627-69-2

  • Molecular Formula: C₉H₁₄N₄O₅

  • Molecular Weight: 258.23 g/mol

  • Chemical Structure: 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside

  • Synonyms: Acadesine, AICA Riboside, ZMP Precursor, NSF 2627692

Research Highlights

  • Direct Allosteric AMPK Activation: Converted intracellularly to ZMP, an AMP mimetic that engages AMPK signaling without altering intracellular ATP/ADP ratios.

  • Insulin-Independent Glucose Transport: Extensively utilized in skeletal muscle tissue assays to investigate GLUT4 translocation and non-insulin-mediated glucose uptake mechanisms.

  • Mitochondrial Biogenesis Signaling: Evaluated for its capacity to stimulate PGC-1α gene expression, promoting mitochondrial density and oxidative capacity in metabolic models.

  • Fatty Acid Oxidation Kinetics: Studied for its role in inhibiting acetyl-CoA carboxylase (ACC) activity, shifting cellular energy substrate utilization toward lipid oxidation.

  • Exercise Mimetic Reference Standard: Functions as a benchmark probe in exercise physiology models to mimic cellular energy-demand signaling in vitro.

  • Analytical Purity Verification: Fully verified via third-party HPLC testing ((≥ 99% purity) to eliminate contaminant-driven variances in enzyme kinetic assays.

Product Specifications

  • Physical Form: Solid lyophilized powder

  • Visual Appearance: White to off-white crystalline powder

  • Purity Level: (≥ 99% (HPLC Verified)

  • Solubility: Soluble in sterile water, bacteriostatic water, or DMSO

  • Storage Requirements:

    • Unopened (Lyophilized): Keep tightly sealed and dry at -20°C for long-term storage (or 2–8°C for short-term handling). Protect from light and atmospheric moisture.

    • Reconstituted Solution: Store under refrigeration at 2°C – 8°C. Aliquot working stock solutions into single-use volumes to prevent degradation from repeated freeze-thaw cycles.

  • Usage Disclaimer: Strictly for In Vitro Laboratory Research and Development Use Only. Must be handled by qualified professionals. Not for human, therapeutic, or diagnostic applications.

Research Studies

Frequently Asked Questions

Are your peptides lab tested?

Yes, all our products are tested by third-party laboratories.
COAs are available per batch.

Why is my peptide not dissolving properly?

Some peptides dissolve slower than others.
Using bacteriostatic water or first adding a small amount of acetic acid can improve dissolution.

Why does my peptide look different?

Peptides can appear as powder, flakes, or a solid “puck”.
This is normal and caused by the freeze-drying process — it does not affect quality.

How should I store peptides?

  • Long-term: freezer (-18 to -20°C)
  • After mixing: refrigerator (2–8°C)
  • Always keep away from light and heat

Are your products for human consumption?

No. All products are sold strictly for research purposes only.
They are not intended for human or animal use.

Do you offer refunds or reships?

We handle issues case-by-case.
If there is a problem with your order (damage, delivery issue), we will always work towards a solution including reshipment where appropriate.