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Safe Vials

CJC-1295 No-DAC 10mg

CJC-1295 No-DAC 10mg

+99% Purity Third-Party Tested COA Available
$91.00
$91.00
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Strictly for laboratory research and development use only. Not for human, therapeutic, or diagnostic applications.

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Description

Safe Vials CJC-1295 No-DAC (also known as Modified GRF 1–29) is a high-purity, synthetic 29-amino acid growth hormone-releasing hormone (GHRH) analog engineered with four strategic amino acid substitutions relative to native GRF. These structural alterations protect the peptide against rapid enzymatic degradation—most notably a D-alanine substitution at position 2 that prevents cleavage by dipeptidyl peptidase-4 (DPP-4).

Unlike variants containing the Drug Affinity Complex (DAC), Safe Vials CJC-1295 No-DAC does not bind to serum albumin, resulting in a short half-life measured in minutes rather than days. This rapid clearance profile permits tight temporal control over the stimulus window, inducing a discrete, physiological pulse of growth hormone secretion rather than continuous, sustained elevation. It serves as an essential reference standard for investigating growth hormone axis kinetics, downstream IGF-1 response, and pituitary receptor signaling. Every lot is independently third-party tested and HPLC-verified (≥ 99% purity) to ensure maximum laboratory reproducibility.

Compound Information

  • Product Name: Safe Vials CJC-1295 No-DAC

  • Classification: Growth Hormone Secretagogue / GHRH Analog

  • CAS Registry Number: 863288-34-0

  • Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂

  • Molecular Weight: 3367.90 g/mol

  • Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-$\text{NH}_2$ (29 Amino Acids)

  • Synonyms: Modified GRF (1–29), Mod GRF 1-29, CJC-1295 DAC-free

Research Highlights

  • Pulsatile GH Release Dynamics: Short functional half-life produces a sharp, discrete growth hormone pulse, preserving natural, pulsatile secretion patterns in research models.

  • DPP-4 Cleavage Resistance: Incorporates D-Ala at position 2 to block dipeptidyl peptidase-4 degradation, enhancing stability compared to native GHRH(1–29).

  • No Albumin Binding (DAC-Free): Rapid clearance gives researchers precise temporal control over pituitary receptor exposure without long-term systemic elevation.

  • GH–IGF-1 Axis Baseline: Acts as a standard reference compound for evaluating downstream hepatic IGF-1 transcription and somatotroph responsiveness.

  • Endogenous Pituitary Stimulation: Operates upstream at GHRH receptors on pituitary somatotrophs to stimulate endogenous growth hormone synthesis rather than introducing exogenous somatotropin.

  • Analytical Purity Verification: Fully verified via third-party HPLC testing (≥ 99% purity) to guarantee batch-to-batch consistency across long study timelines.

Product Specifications

  • Physical Form: Solid lyophilized powder

  • Visual Appearance: White to off-white cake/powder

  • Purity Level: ≥ 99% (HPLC Verified)

  • Solubility: Readily soluble in sterile water or bacteriostatic water

  • Storage Requirements:

    • Unopened (Lyophilized): Keep tightly sealed and dry at -20°C for long-term storage (or 2–8°C for short-term handling). Protect from light exposure and moisture.

    • Reconstituted Solution: Store under refrigeration at 2°C – 8°C. Aliquot working stock solutions to prevent structural degradation from repeated freeze-thaw cycles.

  • Usage Disclaimer: Strictly for In Vitro Laboratory Research and Development Use Only. Must be handled by qualified professionals. Not for human, therapeutic, or diagnostic applications.

Research Studies

Frequently Asked Questions

Are your peptides lab tested?

Yes, all our products are tested by third-party laboratories.
COAs are available per batch.

Why is my peptide not dissolving properly?

Some peptides dissolve slower than others.
Using bacteriostatic water or first adding a small amount of acetic acid can improve dissolution.

Why does my peptide look different?

Peptides can appear as powder, flakes, or a solid “puck”.
This is normal and caused by the freeze-drying process — it does not affect quality.

How should I store peptides?

  • Long-term: freezer (-18 to -20°C)
  • After mixing: refrigerator (2–8°C)
  • Always keep away from light and heat

Are your products for human consumption?

No. All products are sold strictly for research purposes only.
They are not intended for human or animal use.

Do you offer refunds or reships?

We handle issues case-by-case.
If there is a problem with your order (damage, delivery issue), we will always work towards a solution including reshipment where appropriate.