GHK-Cu

Safe Vials GHK-Cu is a high-purity, laboratory-grade copper-binding tripeptide (glycyl-L-histidyl-L-lysine chelated with a copper(II) ion) supplied in lyophilized powder form. First isolated from human plasma in the 1970s—where endogenous concentrations naturally decline with age—GHK-Cu is extensively studied for its pivotal role in regulating extracellular matrix turnover, promoting collagen and glycosaminoglycan synthesis, and modulating copper-dependent enzymatic pathways.

Engineered for optimal stability and batch-to-batch reproducibility, Safe Vials GHK-Cu features a characteristic deep blue hue indicating an authentic, fully chelated copper(II) square-planar complex. Every lot undergoes independent third-party HPLC verification to ensure ≥99% purity for demanding in vitro assays and advanced research protocols.

Compound Information

• Product Name: Safe Vials GHK-Cu

• Chemical Name: Glycyl-L-histidyl-L-lysine copper(II) complex

• Type: Endogenous Matrix Signal / Copper-Binding Tripeptide

• CAS Registry Number: 89030-95-5

• Molecular Formula: C₁₄H₂₄CuN₆O₄

• Molecular Weight: 403.94 g/mol (copper complex)

• Amino Acid Sequence: Gly-His-Lys · Cu²⁺

• Synonyms: Copper Peptide, GHK-Copper, Gly-His-Lys Cu(II)

Research Highlights

• Chelated Biological Signal: Features a high-affinity square-planar coordinate complex between the tripeptide and a Cu²⁺ ion, ensuring the true biologically active signaling form is maintained throughout testing.

• Extracellular Matrix Remodeling: Widely investigated in research models for driving collagen and glycosaminoglycan expression, as well as balancing metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs).

• Broad Gene Modulation: Expression-profiling studies demonstrate that GHK-Cu modulates a extensive array of human genes tied to cellular repair, tissue regeneration, and antioxidant defense.

• Cuproenzyme Activation: Acts as an essential reference compound in studies evaluating copper-dependent enzymes, such as lysyl oxidase (critical for collagen cross-linking).

• Third-Party Analytical Verification: Each batch is verified via HPLC to confirm a minimum of 99% purity and accurate peptide content prior to distribution.

Product Specifications

• Physical Form: Solid lyophilized powder

• Visual Appearance: Distinctive blue to blue-green powder (indicative of active copper chelation)

• Purity Level: ≥ 99% (HPLC Verified)

• Solubility: Readily soluble in sterile water or bacteriostatic water

• Storage Requirements:

  • Lyophilized (Unopened): Store sealed and dry at -20°C for long-term storage (or 2–8°C for short-term handling). Keep shielded from direct light.

  • Reconstituted Solution: Store under refrigeration at 2°C – 8°C. Avoid repeated freeze-thaw cycles.

• Usage Disclaimer: Strictly for In Vitro Laboratory Research and Development Use Only. Not for human consumption, therapeutic, or diagnostic applications.