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Safe Vials

IGF-1 LR3 1mg

IGF-1 LR3 1mg

+99% Purity Third-Party Tested COA Available
$118.00
$118.00
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Strictly for laboratory research and development use only. Not for human, therapeutic, or diagnostic applications.

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Description

Safe Vials IGF-1 LR3 (Long R3 IGF-1) is a high-purity, laboratory-grade recombinant analog of human insulin-like growth factor 1. Engineered as an 83-amino acid protein, it incorporates two major modifications relative to native IGF-1: a glutamic acid-to-arginine substitution at position 3 (Arg³) and a 13-amino acid extension on its N-terminus.

Both structural alterations work synergistically to drastically reduce the protein’s binding affinity for IGF-binding proteins (IGFBPs). In native biological systems, IGFBPs sequester circulating IGF-1, rendering it inactive. By resisting IGFBP complexation, Safe Vials IGF-1 LR3 remains freely available to engage the IGF-1 receptor (IGF-1R), driving the downstream PI3K/Akt signaling cascade that regulates cellular proliferation, survival, and protein synthesis. Every lot is independently third-party tested and HPLC-verified (≥ 95% purity) to ensure maximum activity and inter-assay consistency.

Compound Information

  • Product Name: Safe Vials IGF-1 LR3

  • Classification: Recombinant Growth Factor Analog (IGF-1R Agonist)

  • CAS Registry Number: 946870-92-4

  • Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉

  • Molecular Weight: 9111.00 g/mol (approx.)

  • Structure & Length: 83 Amino Acids (70 AA IGF-1 core + 13 AA N-terminal extension, Arg³ substitution, 3 internal disulfide bridges)

  • Synonyms: Long R3 IGF-1, LR3 IGF-1, Recombinant Human IGF-1 LR3

Research Highlights

  • Resistance to IGFBP Sequestration: The Arg³ mutation and N-terminal extension sharply lower affinity for binding proteins, maintaining high free concentration for receptor interaction.

  • Cell Culture Media Standard: Widely utilized as a core supplement in serum-free and reduced-serum media, offering higher functional availability than native IGF-1.

  • PI3K/Akt Pathway Engagement: Binds IGF-1R to activate the central PI3K/Akt signaling cascade, a foundational axis in cell survival and protein synthesis research.

  • Myoblast & Fibroblast Proliferation: Frequently applied in muscle cell and tissue engineering protocols to track cell division and proliferation rates.

  • Folded Protein Dynamics: Features three essential intra-molecular disulfide bridges that maintain the tertiary structure necessary for receptor activation.

  • Analytical Quality Control: Independently verified via third-party HPLC (≥ 95% purity) to guarantee reliable, batch-to-batch operational activity.

Product Specifications

  • Physical Form: Solid lyophilized powder

  • Visual Appearance: Fine white to off-white cake/powder

  • Purity Level: ≥ 95% (HPLC Verified)

  • Solubility: Soluble in dilute acetic acid or bacteriostatic water

  • Storage Requirements:

    • Unopened (Lyophilized): Keep sealed and dry at -20°C for long-term preservation (or 2–8°C for short-term handling). Protect from direct light.

    • Reconstituted Solution: Store under refrigeration at 2°C – 8°C. Aliquot into single-use working volumes; avoid repeated freeze-thaw cycles, high heat, physical agitation, or strong reducing agents that break disulfide bridges.

  • Usage Disclaimer: Strictly for In Vitro Laboratory Research and Development Use Only. Must be handled by qualified professionals. Not for human, therapeutic, or diagnostic applications.

Research Studies

Frequently Asked Questions

Are your peptides lab tested?

Yes, all our products are tested by third-party laboratories.
COAs are available per batch.

Why is my peptide not dissolving properly?

Some peptides dissolve slower than others.
Using bacteriostatic water or first adding a small amount of acetic acid can improve dissolution.

Why does my peptide look different?

Peptides can appear as powder, flakes, or a solid “puck”.
This is normal and caused by the freeze-drying process — it does not affect quality.

How should I store peptides?

  • Long-term: freezer (-18 to -20°C)
  • After mixing: refrigerator (2–8°C)
  • Always keep away from light and heat

Are your products for human consumption?

No. All products are sold strictly for research purposes only.
They are not intended for human or animal use.

Do you offer refunds or reships?

We handle issues case-by-case.
If there is a problem with your order (damage, delivery issue), we will always work towards a solution including reshipment where appropriate.