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Description
Safe Vials Kisspeptin-10 is a high-purity, laboratory-grade synthetic 10-amino acid neuropeptide representing the minimal C-terminal bioactive fragment of the endogenous KISS1 gene product (metastin). It serves as a primary, functional molecular probe to investigate kisspeptin-mediated signaling independently of full-length or precursor peptides.
Within cellular and neuroendocrine research systems, Safe Vials Kisspeptin-10 acts as a high-affinity agonist for the KISS1 receptor (KISS1R / GPR54), a G-protein-coupled receptor predominantly expressed on hypothalamic gonadotropin-releasing hormone (GnRH) neurons. It is widely utilized in scientific studies investigating the hypothalamic-pituitary-gonadal (HPG) axis, gonadotropin secretion kinetics (LH and FSH release), and reproductive endocrine signaling. Every lot is independently third-party tested and HPLC-verified (≥ 99% purity) to guarantee high experimental reproducibility.
Compound Information
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Product Name: Safe Vials Kisspeptin-10
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Classification: Synthetic Neuropeptide Fragment / KISS1R (GPR54) Agonist
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CAS Registry Number: 374675-21-5
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Molecular Formula: C₆₃H₈₃N₁₇O₁₄
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Molecular Weight: 1302.44 g/mol
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Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (10 Amino Acids, C-terminally amidated)
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Synonyms: Metastin (45–54), KiSS-1 derived decapeptide, KISS1R Ligand Fragment
Research Highlights
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Minimal Bioactive Fragment: Retains full binding affinity and potent agonist activity for the KISS1R (GPR54) receptor while offering a compact sequence for controlled signaling assays.
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HPG Axis Upstream Regulation: Acts as a standard reference peptide for probing hypothalamic GnRH pulse generator activity and downstream pituitary LH/FSH secretion.
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G-Protein Coupled Receptor Dynamics: Extensively applied in in vitro binding and functional assays to track Gαq/11-coupled intracellular calcium mobilization.
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Pubertal & Reproductive Model Standard: Serves as a fundamental tool in neuroendocrine models evaluating central reproductive maturation, feedback loops, and fertility pathways.
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C-Terminal Amidation Stability: Features a hydrophobic, amidated C-terminus essential for receptor engagement and structural stabilization against exopeptidase cleavage in research media.
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Analytical Purity Verification: Fully verified via third-party HPLC testing (≥ 99% purity) to ensure batch-to-batch consistency and accurate quantitative assay design.
Product Specifications
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Physical Form: Solid lyophilized powder
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Visual Appearance: Fine white to off-white cake/powder
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Purity Level: ≥ 99% (HPLC Verified)
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Solubility: Readily soluble in sterile water or buffered aqueous solutions
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Storage Requirements:
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Unopened (Lyophilized): Keep tightly sealed, desiccated, and stored at -20°C for long-term preservation (or 2–8°C for short-term handling). Protect from light exposure.
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Reconstituted Solution: Store under refrigeration at 2°C – 8°C. Aliquot working stock solutions to prevent structural degradation from repeated freeze-thaw cycles.
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Usage Disclaimer: Strictly for In Vitro Laboratory Research and Development Use Only. Must be handled by qualified professionals. Not for human, therapeutic, or diagnostic applications.