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Safe Vials

LL-37 5mg

LL-37 5mg

+99% Purity Third-Party Tested COA Available
$73.00
$73.00
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Strictly for laboratory research and development use only. Not for human, therapeutic, or diagnostic applications.

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Description

Safe Vials LL-37 is a high-purity, laboratory-grade synthetic 37-amino acid cationic peptide corresponding to the C-terminal fragment of human cathelicidin (hCAP18). As the sole cathelicidin-derived antimicrobial peptide identified in humans, LL-37 plays a foundational role in host defense mechanisms across mucosal and epithelial surfaces.

Characterized by its amphipathic α-helical conformation and high net positive charge, Safe Vials LL-37 is widely utilized in lipid bilayer disruption models to examine non-specific membrane interaction dynamics. Beyond direct antimicrobial activity, it serves as an indispensable signaling reference probe in immunomodulatory research—specifically for evaluating cell recruitment via chemotaxis, pro- and anti-inflammatory cytokine expression, and cell migration in re-epithelialization and wound-healing assays. Every lot is independently third-party tested and HPLC-verified (≥ 98% purity) to guarantee high batch-to-batch consistency and reproducible quantitative results.

Compound Information

  • Product Name: Safe Vials LL-37

  • Classification: Cationic Antimicrobial Peptide (Cathelicidin / AMP)

  • CAS Registry Number: 154947-66-7

  • Molecular Formula: C₂₀₅H₃₄₀N₆₀O₅₃

  • Molecular Weight: 4493.33 g/mol

  • Sequence: Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser (37 Amino Acids)

  • Synonyms: Cathelicidin, hCAP18 (104–140), CAMP

Research Highlights

  • Human Cathelicidin Benchmark: Serves as the primary human cathelicidin reference compound for studying innate host-defense mechanisms at skin and mucosal interfaces.

  • Amphipathic Membrane Interactions: The cationic $\alpha$-helical structure makes it an essential model for examining electrostatic attraction to anionic lipid bilayers and membrane disruption kinetics.

  • Immunomodulatory & Chemotactic Signaling: Widely applied in cell culture protocols to monitor immune cell recruitment, receptor interaction (e.g., FPR2), and downstream cytokine cascades.

  • Epithelial Repair & Angiogenesis: Evaluated in wound-healing models to observe keratinocyte migration, re-epithelialization rates, and endothelial tube formation.

  • Broad Antimicrobial Standard: Functions as a control benchmark in comparative assays evaluating novel synthetic antimicrobial peptide candidates.

  • Analytical Purity Verification: Independently verified via third-party HPLC testing (≥ 98% purity) to ensure clean, consistent performance in analytical protocols.

Product Specifications

  • Physical Form: Solid lyophilized powder

  • Visual Appearance: Fine white to off-white cake/powder

  • Purity Level: ≥ 98% (HPLC Verified)

  • Solubility: Readily soluble in sterile water or bacteriostatic water (Note: Highly cationic peptide—use low-binding plasticware where possible to minimize surface adsorption)

  • Storage Requirements:

    • Unopened (Lyophilized): Keep tightly sealed and dry at -20°C for long-term storage (or 2–8°C for short-term handling). Protect from light and moisture.

    • Reconstituted Solution: Store under refrigeration at 2°C – 8°C. Aliquot working stock solutions to prevent structural degradation from repeated freeze-thaw cycles.

  • Usage Disclaimer: Strictly for In Vitro Laboratory Research and Development Use Only. Must be handled by qualified professionals. Not for human, therapeutic, or diagnostic applications.

Research Studies

Frequently Asked Questions

Are your peptides lab tested?

Yes, all our products are tested by third-party laboratories.
COAs are available per batch.

Why is my peptide not dissolving properly?

Some peptides dissolve slower than others.
Using bacteriostatic water or first adding a small amount of acetic acid can improve dissolution.

Why does my peptide look different?

Peptides can appear as powder, flakes, or a solid “puck”.
This is normal and caused by the freeze-drying process — it does not affect quality.

How should I store peptides?

  • Long-term: freezer (-18 to -20°C)
  • After mixing: refrigerator (2–8°C)
  • Always keep away from light and heat

Are your products for human consumption?

No. All products are sold strictly for research purposes only.
They are not intended for human or animal use.

Do you offer refunds or reships?

We handle issues case-by-case.
If there is a problem with your order (damage, delivery issue), we will always work towards a solution including reshipment where appropriate.