MOTS-C

Safe Vials MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a high-purity, laboratory-grade 16-residue peptide derived directly from the mitochondrial genome rather than nuclear DNA. Belonging to an emerging class of mitochondrial-derived peptides (MDPs), MOTS-c serves as a critical retrograde signaling molecule that translocates from the mitochondrion to the nucleus to regulate stress-responsive nuclear gene expression.

Specifically engineered for high reproducibility across research protocols, Safe Vials MOTS-c is widely utilized in studies evaluating AMP-activated protein kinase (AMPK) activation, cellular energy regulation, skeletal muscle glucose handling, and folate–methionine pathway dynamics. Every lot is HPLC-verified to ensure maximum purity, providing researchers with a dependable, contaminant-free standard for advanced in vitro and cellular assays.

Compound Information

• Product Name: Safe Vials MOTS-c

• Classification: Mitochondrial-Derived Peptide (MDP) / Metabolic Regulator

• CAS Registry Number: 1627580-64-6

• Molecular Formula: C₁₀₁H₁₅₁N₂₉O₂₂S₂

• Molecular Weight: 2174.62 g/mol

• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (16 Amino Acids)

• Gene Origin: Encoded within the mtDNA 12S rRNA region

Research Highlights

• Retrograde Nuclear Signaling: Acts as an essential reference model for retrograde signaling, demonstrating how mitochondrial activity directly influences nuclear transcription during cellular stress.

• AMPK Pathway Engagement: Actively researched alongside compounds like AICAR for its role in stimulating AMP-activated protein kinase (AMPK) and promoting metabolic equilibrium.

• Glucose Homeostasis & Insulin Sensitivity: Extensively cited in skeletal muscle and systemic metabolic models examining cellular glucose uptake and metabolic flexibility.

• Folate–Methionine Cycle Interaction: Modulates one-carbon metabolism, offering insights into the regulatory link between mitochondrial signaling and nuclear methylation processes.

• High-Purity Stability: Supplied in a verified, highly stable lyophilized format to maintain peptide structural integrity over prolonged laboratory studies.

Product Specifications

• Physical Form: Solid lyophilized powder

• Visual Appearance: Fine white to off-white powder

• Purity Level: ≥ 98% (HPLC verified)

• Solubility: Soluble in sterile water or bacteriostatic water

• Storage & Stability Requirements:

  • Unopened (Lyophilized): Keep sealed and dry at -20°C for long-term storage (or 2–8°C for short-term handling). Protect from light and moisture. Note: Contains methionine residues—minimize direct exposure to air and strong oxidizing agents.

  • Reconstituted Solution: Aliquot and store under refrigeration at 2°C – 8°C. Avoid repeated freeze-thaw cycles to preserve peptide structure.

• Usage Disclaimer: Strictly for In Vitro Laboratory Research and Development Use Only. Not for human consumption, therapeutic, or diagnostic applications.