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Safe Vials

TB500 10mg

TB500 10mg

+99% Purity Third-Party Tested COA Available
$91.00
$91.00
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Strictly for laboratory research and development use only. Not for human, therapeutic, or diagnostic applications.

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Description

Safe Vials TB-500 is a high-purity, laboratory-grade synthetic 7-amino acid peptide corresponding specifically to the active actin-binding domain (Ac-LKKTETQ) of Thymosin Beta-4 (Tβ₄). While naturally occurring Tβ₄ is a full-length 43-residue protein, isolating this essential heptapeptide fragment provides researchers with a highly stable, compact, and easily dissolvable tool to study cytoskeletal dynamics without the handling complexity of the parent protein.

Engineered with an N-terminal acetyl cap for enhanced metabolic stability against enzymatic cleavage, Safe Vials TB-500 regulates the monomeric G-actin pool available for microfilament polymerization. This mechanism makes it a fundamental reference compound for in vitro scratch assays, directional cell motility studies, and vascular endothelial network formation. Every lot is independently third-party tested and HPLC-verified (≥ 99% purity) to ensure precise concentration and maximum experimental reproducibility.

Compound Information

  • Product Name: Safe Vials TB-500

  • Classification: Thymosin Tβ₄ Fragment / Actin-Binding Domain

  • CAS Registry Number: 885340-08-9

  • Molecular Formula: C₃₇H₆₅N₁₁O₁₃

  • Molecular Weight: 888.00 g/mol

  • Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (7 Amino Acids, N-terminally acetylated)

  • Synonyms: Tβ₄ Fragment (17–23), Thymosin Beta-4 Active Domain, Ac-LKKTETQ

Research Highlights

  • Targeted Actin Sequestration: Faithfully reproduces the core LKKTETQ motif responsible for binding monomeric G-actin, directly influencing filament assembly and cellular architectural remodeling.

  • Cell Migration & Motility: Widely utilized in transwell migration and scratch assays to measure cytoskeletal reorganization velocity and cellular motility patterns in vitro.

  • Vascular & Angiogenic Signaling: Frequently investigated in endothelial cell models to examine capillary tube formation and tissue remodeling pathways.

  • Acetylated N-Terminus Stability: Features an acetyl cap at the N-terminus that significantly improves peptide stability against aminopeptidase degradation compared to free-amine variants.

  • Compact & Efficient Handling: The 7-residue sequence is significantly simpler to handle, reconstitute, and dose than full-length 43-residue Tβ₄ while isolating its core active region.

  • Analytical Purity Verification: Independently tested and HPLC-verified (≥ 99% purity) to ensure reliable, batch-to-batch consistency across extended research protocols.

Product Specifications

  • Physical Form: Solid lyophilized powder

  • Visual Appearance: Fine white to off-white cake/powder

  • Purity Level: ≥ 99% (HPLC Verified)

  • Solubility: Readily soluble in sterile water or bacteriostatic water

  • Storage Requirements:

    • Unopened (Lyophilized): Keep sealed and dry at -20°C for long-term preservation (or 2–8°C for short-term handling). Protect from direct light and atmospheric moisture.

    • Reconstituted Solution: Store under refrigeration at 2°C – 8°C. Aliquot working stocks to prevent degradation from repeated freeze-thaw cycles.

  • Usage Disclaimer: Strictly for In Vitro Laboratory Research and Development Use Only. Not for human consumption, therapeutic, or diagnostic applications.

Research Studies

Frequently Asked Questions

Are your peptides lab tested?

Yes, all our products are tested by third-party laboratories.
COAs are available per batch.

Why is my peptide not dissolving properly?

Some peptides dissolve slower than others.
Using bacteriostatic water or first adding a small amount of acetic acid can improve dissolution.

Why does my peptide look different?

Peptides can appear as powder, flakes, or a solid “puck”.
This is normal and caused by the freeze-drying process — it does not affect quality.

How should I store peptides?

  • Long-term: freezer (-18 to -20°C)
  • After mixing: refrigerator (2–8°C)
  • Always keep away from light and heat

Are your products for human consumption?

No. All products are sold strictly for research purposes only.
They are not intended for human or animal use.

Do you offer refunds or reships?

We handle issues case-by-case.
If there is a problem with your order (damage, delivery issue), we will always work towards a solution including reshipment where appropriate.